Geref (Serono Pharma)

Geref (Serono Pharma) - General Information

Geref (Serono Pharma) acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues

Pharmacology of Geref (Serono Pharma)

Geref (Serono Pharma) is used in the treatment of children with growth hormone deficiency or growth failure. Geref increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Geref is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans.

Geref (Serono Pharma) for patients

Geref (Serono Pharma) Interactions

Concomitant glucocorticoid therapy may inhibit the response to Geref�. There was no evidence in the controlled studies of Geref�'s interaction with drugs commonly used in the treatment of routine pediatric problems/illnesses. However, formal drug interactions studies have not been conducted.

Geref (Serono Pharma) Contraindications

Geref� (sermorelin acetate for injection) should not be used by patients with a known sensitivity to sermorelin or any of the excipients.

Additional information about Geref (Serono Pharma)

Geref (Serono Pharma) Indication: For the treatment of dwarfism, prevention of HIV-induced weight loss
Mechanism Of Action: Geref (Serono Pharma) binds to the growth hormone releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sermorelin
Synonyms: Geref
Drug Category: Anabolic Agents; Hormone Replacement Agents
Drug Type: Biotech; Approved

Other Brand Names containing Sermorelin: Geref (Serono Pharma);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 11-12 min
Dosage Forms of Geref (Serono Pharma): Injection, powder, lyophilized, for solution Subcutaneous
Chemical IUPAC Name: 3-[[5-amino-2-[[2-[[2-[[6-amino-2-[[2-[2-[[2-[[2-[[5-amino-2-[[2-[[2-[[2-[[6-amino-2-[[2-[[2-[[2-[[4-amino-2-[[2-[[2-[[2-[2-[[2-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-hydroxy-4-oxobutanoyl]amino]propanoylamino]-3-methylpentanoyl]amino]-3-cyclohexylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoylamino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-4-[[1-[[1-[[1-[(1-amino-5-carbamimidamido-1-oxopentan-2-yl)amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Chemical Formula: C149H246N44O42S
Sermorelin on Wikipedia: https://en.wikipedia.org/wiki/Sermorelin
Organisms Affected: Humans and other mammals